(Pneumococcus) is a leading cause of serious disease among children worldwide []. In total immunization of the child with pneumococcal conjugated vaccine in the United States, p
pneumonia caused about 17,000 cases of invasive disease every year among children under five years, including 700 cases of meningitis and 200 death [
]. It was the most common cause of bacteremia, bacterial pneumonia, bacterial meningitis, sinusitis and acute otitis media [
]. Since pneumococcal been added to the normal schedule of immunization of children in the United States, the incidence of invasive pneumococcal infections decreased by 60 to 90 percent of children under two years. (See below
). Use
conjugated pneumococcal vaccine in children will be presented here. Pneumococcal polysaccharide vaccines in children, pneumococcal vaccination in adults and the impact of universal infant immunization with pneumococcal conjugated vaccine in the U.S. is discussed separately. (See
and s).
C. pneumonia strattera cost causes a type of protective immune response and provides the basis for serotypuvannya these organisms. More than 90 different serotypes of pneumococcus were found. Serotypes 4, 6B, 9V, 14, 18C, 19F and 23F are the most common in children, representing 60 to 80 percent of infections, depending on the region of the world. (See)
currently not possible to include all 90 serotypes in the vaccine or polysaccharide polysaharydnoy-connected. Pneumococcal polysaccharide vaccines represent subgroups of 14 and 23 most common serotypes causing invasive disease were developed in the 1970s and 1980s (PPSV14 and PPSV23, respectively) [
]. Pneumococcal polysaccharide vaccines are discussed separately. (See
s).
Polysaccharide vaccines poorly immunogenic in children younger than two years [], in the age group with the highest rate of invasive disease [
]. However, a couple of immunogenic proteins nonpneumococcal (protein carrier) to separate polysaccharides pneumococcus causes T-cell memory depends on the reaction and increases the effectiveness of a vaccine for the first two years of life. Carrier proteins for pneumococcal conjugate vaccine include CRM197 (nontoxic diphtheria toxin mutant) and OMP (outer membrane protein complex from
). Combined vaccines including pneumococcal proteins are under development, to expand protection for the capsule type. .
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